CartSoft and its C.A.R.T.-UM program utilize the Milliman Care Guidelines. The guidelines are written by physicians and nurses, chronicling the best practices for patient care from medical literature, practice observation and the expert opinions of physicans, nurses and other healthcare professionals.

The evidence-based guidelines are widely accepted by leading medical journals, physicians and medical schools. Today, the treatment of one out of every four patients is based on Milliman Care Guidelines. However, they are not intended to replace the professional judgment of physicians or nurses. Simply stated Milliman evidence-based guidelines gives physicians and nurses the most comprehensive collection of information on "best practices" that can assist in making clinical decisions for individual patients.

The guidelines used in C.A.R.T.-UM measure a patient's clinical day, matching the patient's progress against an optimal recovery rather than a single absolute yes or no test.

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